Everything is in the mind

Each and everyone must be aware of the fact that successful diet is all in the mind.A protein found in cells throughout the body must exist in a specific set of brain neurons to prevent weight gain after chronic feeding on high-calorie meals.

It is called as longevity protein because of its apparent role in mediating the effects of dietary restriction on life span.The research has also shown that this metabolic sensor protein in peripheral tissues plays an important role in regulating metabolism, but its physiological relevance in brain neurons remained unclear.Commonly known as POMC, or proopiomelanocortin, neurons are found in the hypothalamus region of the brain and are known to play an important role in suppressing appetite and inducing weight loss.

In addition, the researchers found that SIRT1 must be present in POMC neurons for leptin to stimulate the remodeling of white adipose tissue into brown fat tissue, which "burns" fat to generate heat.

The researcher has said  said the idea of a drug that selectively could target neurons controlling specific fat depots and that could trigger the remodelling of white fat into brown fat has high potential.